Together with a group of neuropathologists, in 2014 we established consensus criteria for a new category of neuropathologic change, termed primary age-related tauopathy (PART). Individuals with PART display AD-type neurofibrillary tangles (NFT) in the medial temporal lobe in the absence of Aβ plaques. Patients with PART may have normal cognition, amnestic mild cognitive impairment (aMCI), or an amnestic dementia. The following dataset contains hippocampal and frontal cortex post-mortem brain sections stained for luxol fast blue H&E, hyperphosphorylated tau (AT8, ptau) and beta amyloid (4G8). The sections were collected from numerous brain banks across the world and restained and digitized through a partnership between the University of Texas Southwestern and the Icahn School of Medicine at Mount Sinai. PIs and/or contributors: John F. Crary, MD-PhD, john.crary@mountsinai.org, Kurt Farrell, PhD, kurt.farrell@mssm.edu Publication link : https://doi.org/10.1093/jnen/nlaa153, https://link.springer.com/article/10.1007/s00401-021-02379-z,https://pubmed.ncbi.nlm.nih.gov/25348064/ Citation requirements: Please cite the following 3 publications listed above Data Dictionary: Please...
Access requires approval by the data custodian. The collection's description and structure are public; querying the data requires an approved request.
Primary age-related tauopathy (PART) slide collection is published on 10kBrains.